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A triumph of Internet-based Collective Code Ownership. The Himalayas inspired Workman to pursue mountaineering. Although co-localization of PKB and PDK1 at the plasma membrane through their mutual interaction with 3-phosphoinositides is likely to be important for PDK1 to phosphorylate PKB, the binding of PKB to PtdIns(3,4,5)P3 or PtdIns(3,4)P2 is also postulated to induce a conforma- tional change in PKB, exposing Thr308 for phosphorylation by PDK1.

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