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Such changes - including scale-up - should be reported. For example, if X, Y, and Z are each subexpressions (which could be anything from a single constant or variable reference to a complex expression in and of themselves), then an expression of the form X Y Z does not imply that the compiler computes the value for X before it computes the value for Y and Z. The inverse of every operator is in the group.

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The normalized metrics AUCRAUC and AUCeAUC do not contain this confounding and should be more sensitive than Cmax and the unnormalized partial AUCs at detecting true differences in rate of absorption.

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